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Wyoming vs. Colorado Prediction, Betting Odds & How To Watch

Colton Pool by Colton Pool
September 19, 2025
Wyoming quarterback Kaden Anderson

AP Photo/Rick Scuteri

After a disappointing 2024 campaign, this season has been much better for Wyoming already in Jay Sawvel’s second year as head coach.

The Cowboys started off with back-to-back wins over Akron on the road and Northern Iowa at home. They’re 2-1 after losing to No. 20-ranked Utah 31-6 a week ago.

Wyoming has a decent shot of pulling off a Group of Five-Power Four upset this week against a struggling Colorado squad.

The Buffaloes are 1-2 overall. They lost to Georgia Tech 27-20 and Houston 36-20 with a 31-7 win over Delaware in between those matchups.


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Wyoming vs. Colorado College Football Betting

Colorado is a -12.5 college football betting odds favorite against Wyoming, with the Over/Under being 45.5. 

The moneyline for Wyoming is +400, while it’s -550 for Colorado.


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Wyoming vs. Colorado On TV

The matchup between Wyoming and Colorado will be televised on ESPN. 

The game will kick off at 10:15 p.m. ET on Saturday, Sept. 20. The contest is taking place at Folsom Field in Boulder, Colorado.

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Wyoming vs. Colorado Prediction

I predict Colorado will win but Wyoming will cover the 12.5-point spread. I also project the game will go Under 45.5 total points.

It’s tempting to pick Wyoming here because Colorado has struggled this season. But now that we know the Buffaloes are going back to Kaidon Salter at quarterback, I think CU’s offense will start making some improvements.

Though, that may not happen against Wyoming’s defense. The Cowboys have played pretty well on that side of the ball, having shut out Akron on the road. Their defense is the strength of their team, and I think they will have an outstanding performance in this matchup.

CU may find a way to win, but I’m anticipating Wyoming will be fantastic in the trenches and will keep it to a one-score game in what will ultimately be a low-scoring contest.

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