In 2025, four MAC prospects were selected in the NFL Draft. Toledo defensive tackle Darius Alexander was the first MAC player selected, going in the third round to the New York Giants.
Now looking forward, here are the top Mid-American Conference prospects who could be chosen in the 2026 NFL Draft:
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NFL Draft MAC Big Board
| Rank | Player | Position | School |
| 1 | Emmanuel McNeil-Warren | DB | Toledo |
| 2 | Nadame Tucker | EDGE | Western Michigan |
| 3 | Andre Fuller | DB | Toledo |
| 4 | Red Murdock | LB | Buffalo |
| 5 | Avery Smith | DB | Toledo |
