Some talented football players have come out of Group of Five programs, and Central Michigan is no exception.
Here’s a look at NFL Draft picks out of CMU during the Super Bowl era, which began in 1966.
NFL Draft Picks From Central Michigan
| Yr | Rd | Team | Player | Position |
| 2025 | 7 | PIT | Donte Kent | DB |
| 2023 | 7 | GB | Lew Nichols III | RB |
| 2022 | 2 | TAM | Luke Goedeke | OL |
| 2022 | 3 | IND | Bernhard Raimann | OL |
| 2019 | 2 | TAM | Sean Murphy-Bunting | CB |
| 2019 | 6 | HOU | Xavier Crawford | CB |
| 2018 | 5 | MIN | Tyler Conklin | TE |
| 2016 | 6 | DAL | Kavon Frazier | S |
| 2015 | 6 | PIT | Leterrius Walton | DT |
| 2013 | 1 | KAN | Eric Fisher | T |
| 2010 | 6 | CHI | Dan LeFevour | QB |
| 2010 | 6 | PIT | Antonio Brown | WR |
| 2007 | 1 | SFO | Joe Staley | T |
| 2007 | 2 | CHI | Dan Bazuin | DE |
| 2007 | 6 | MIA | Drew Mormino | C |
| 2005 | 4 | CIN | Eric Ghiaciuc | C |
| 2005 | 5 | CIN | Adam Kieft | T |
| 1997 | 7 | NWE | Scott Rehberg | G |
| 1991 | 11 | GNB | J.J. Wierenga | DE |
| 1990 | 12 | PHO | Donnie Riley | RB |
| 1987 | 7 | PHI | Brian Williams | T |
| 1985 | 2 | NWE | Jim Bowman | DB |
| 1985 | 8 | SDG | Curtis Adams | RB |
| 1982 | 9 | PIT | Mike Hirn | TE |
| 1981 | 11 | CIN | Robert Jackson | DB |
| 1980 | 5 | DAL | Gary Hogeboom | QB |
| 1976 | 13 | NWE | James Jones | DB |
| 1975 | 3 | DEN | Mike Franckowiak | RB |
| 1975 | 17 | GNB | Tom Ray | DB |
| 1973 | 3 | KAN | Paul Krause | T |
| 1972 | 13 | GNB | Jesse Lakes | RB |
| 1971 | 13 | OAK | Mick Natzel | DB |
| 1970 | 15 | BUF | Dave Farris | TE |
| 1968 | 9 | STL | Billy Sinkule | DE |
