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Michigan
Opponent: vs. Colorado
After putting USC on upset alert against Utah State in Week 2 before watching the Trojans throttle the Aggies, let's go back for another aggressive alert.
Colorado and Michigan have played just four times and not once since 1997, when the Wolverines won for the third time in the series. And their fifth meeting sees CU as a monster underdog, and rightfully so, as the Buffs haven't reached six wins since 2007 and haven't beat a decent team since 2011 when they stunned an eight-win Utah team in the season finale.
But none of those teams had quarterback Sefo Liufau, who is blossoming into one of the most efficient passers in college football. The senior has completed 74.5 percent of his attempts in 2016, throwing for 522 yards, three scores and zero interceptions.
Michigan's defense hasn't been challenged in two sleep-walking games against Hawai'i and UCF, and could become frustrated with CU's efficient attack. Keep an eye on this one in Ann Arbor.
