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Northern Illinois vs. Mississippi State Prediction, Betting Odds & How To Watch

Colton Pool by Colton Pool
September 19, 2025
Northern Illinois head coach Thomas Hammock

AP Photo/Charles Rex Arbogast

Northern Illinois was predicted to be a contender in the MAC this season, but it hasn’t been smooth so far.

NIU is 1-1 overall. The Huskies won at home against FCS Holy Cross to start the season, and that was by a final score of 19-17. Then they kept it close at Maryland before losing 20-9.

Could NIU pull off a Power Four upset this time around? The Huskies go on the road to take on Mississippi State this week, which is 3-0 with wins over Southern Miss, Arizona State, and Alcorn State.

Northern Illinois vs. Mississippi State College Football Betting

Mississippi State is a -22.5 college football betting odds favorite against Northern Illinois, with the Over/Under being 48.5. 

The moneyline for Northern Illinois is +1100, while it’s -2500 for Mississippi State.


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Northern Illinois vs. Mississippi State On TV

The matchup between Northern Illinois and Mississippi State will be televised on the SEC Network. 

The game will kick off at 4:15 p.m. ET on Saturday, Sept. 20. The contest is taking place at Davis Wade Stadium in Starkville, Mississippi.

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Northern Illinois vs. Mississippi State Prediction

I predict Mississippi State will win but NIU will cover the 22.5-point spread. I also project the game will go Under 48.5 total points.

Except for Mississippi State’s 63-0 win over Alcorn State, the Bulldogs have been solid but not spectacular. In fact, I think NIU could have the toughest defense the Bulldogs have seen this year.

NIU has allowed 37 points in two games against Holy Cross and Maryland. Going back to last season, the Huskies have limited their last six opponents to 20 points or less.

The Huskies have been great on defense, and I think they’ll be strong on that side of the ball again against Mississippi State.

Now, I don’t think the Huskies have the offensive capabilities to keep up with the Bulldogs and win. But I believe NIU could end up making this game ugly and will make the Bulldogs earn every point.

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