Southern Illinois’ 2025 football schedule features eight MVFC games, two FCS non-conference matchups, one non-D1 opponent, and one FBS opponent at Purdue ($500,000 payout).
2025 SIU Football Schedule
8/30 vs Thomas More
9/6 at Purdue
9/13 at UT Martin
9/20 at SEMO
10/4 vs Indiana State
10/11 at North Dakota State
10/18 vs North Dakota
10/25 vs Northern Iowa
11/1 at Murray State
11/8 at Youngstown State
11/15 vs South Dakota
11/22 at Illinois State
Bold indicates MVFC contests
