South Dakota State has had several players selected in the NFL Draft.
Here are the past NFL Draft picks from SDSU, with this list dating back to 1970.
South Dakota State NFL Draft Picks
| Yr | Rd | Team | Player |
| 2024 | 5 | NYJ | Isaiah Davis (RB) |
| 2024 | 4 | PIT | Mason McCormick (OL) |
| 2023 | 3 | GB | Tucker Kraft (TE) |
| 2022 | 7 | PIT | Chris Oladokun (QB) |
| 2022 | 4 | NE | Pierre Strong Jr. (RB) |
| 2019 | 7 | CIN | Jordan Brown (DB) |
| 2018 | 2 | PHI | Dallas Goedert (TE) |
| 2010 | 6 | BUF | Danny Batten (DE) |
| 1999 | 3 | SD | Steve Heiden (TE) |
| 1995 | 7 | GB | Adam Timmerman (OL) |
| 1993 | 7 | SD | Doug Miller (LB) |
| 1986 | 8 | DEN | Bruce Klosterman (LB) |
| 1980 | 7 | SD | Chuck Loewen (OL) |
| 1978 | 5 | NE | Bill Matthews (LB) |
| 1976 | 6 | HOU | Todd Simonsen (OL) |
| 1976 | 14 | MIA | Bob Gissler (LB) |
| 1975 | 1 | DET | Lynn Boden (OL) |
| 1975 | 8 | HOU | Jerry Lawrence (DL) |
| 1973 | 11 | GB | Phil Engle (DL) |
| 1970 | 16 | OAK | Tim Roth (DB) |
