Since the start of the FCS/Division 1-AA, no program in the subdivision has had more NFL Draft picks than Jackson State.
JSU has sent 42 players to the draft since 1979 and had dozens more in previous decades. Here’s a look at the NFL Draft picks from Jackson State since the start of the FCS:
Jackson State NFL Draft Picks
| Yr | Rd | NFL | Player |
| 1979 | 10 | SEA | Robert Hardy (DT) |
| 1979 | 12 | SEA | Jeff Moore (RB) |
| 1980 | 2 | PHI | Perry Harrington (RB) |
| 1981 | 8 | GB | Larry Werts (LB) |
| 1981 | 11 | BUF | Buster Barnett (TE) |
| 1982 | 3 | WAS | Carl Powell (WR) |
| 1982 | 7 | MIA | Larry Cowan (RB) |
| 1983 | 9 | STL | Otis Brown (RB) |
| 1983 | 10 | PHI | Thomas Strauthers (DE) |
| 1983 | 11 | BUF | Larry White (DE) |
| 1984 | 9 | NE | David Windham (LB) |
| 1984 | 11 | ATL | Tommy Norman (WR) |
| 1985 | 2 | BUF | Chris Burkett (WR) |
| 1986 | 2 | TB | Jackie Walker (LB) |
| 1986 | 10 | DEN | Victor Hall (TE) |
| 1987 | 4 | BUf | Leon Seals (DE) |
| 1988 | 6 | ATL | Houston Hoover (OL) |
| 1988 | 9 | SEA | Deatrich Wise (DT) |
| 1988 | 12 | NYJ | Albert Goss (DT) |
| 1989 | 4 | NYG | Lewis Tillman (RB) |
| 1989 | 10 | LAR | Charles Jackson (DT) |
| 1990 | 2 | ATL | Darion Conner (LB) |
| 1990 | 10 | CLE | Mike Wallace (DB) |
| 1990 | 11 | LAR | Ron Lewis (WR) |
| 1991 | 3 | KC | Tim Barnett (WR) |
| 1992 | 2 | DAL | Jimmy Smith (WR) |
| 1992 | 8 | DEN | Dietrich Lockridge (OL) |
| 1993 | 1 | PHI | Lester Holmes (OL) |
| 1993 | 7 | DEN | Tony Kimbrough (WR) |
| 1994 | 2 | MN | Fernando Smith (DE) |
| 1994 | 3 | BUF | Marlo Perry (LB) |
| 1996 | 4 | TB | Eric Austin (DB) |
| 1996 | 7 | JAX | Gregory Spann (WR) |
| 1997 | 5 | BUF | Sean Woodson (DB) |
| 1998 | 5 | NYG | Toby Myles (OL) |
| 1998 | 5 | GB | Corey Bradford (WR) |
| 2000 | 1 | KC | Sylvester Morris (WR) |
| 2000 | 1 | CAR | Rashard Anderson (DB) |
| 2000 | 7 | CLE | Eric Chandler (DE) |
| 2000 | 7 | DEN | Leroy Fields (WR) |
| 2008 | 6 | MN | Jaymar Johnson (WR) |
| 2022 | 6 | DET | James Houston (LB) |
| 2023 | 7 | NE | Isaiah Bolden (DB) |
