Cal will reach 5-0, Florida State will improve to 2-1 in the ACC, and South Carolina will drop to 1-4 with a loss to Kentucky.
There are only 55 FBS games in Week 5, the fewest thus far this season thanks to several byes and only one FCS matchup (Nicholls at Texas State). The week opens with Navy at Memphis on Thursday night and closes with Hawai'i at Nevada on Saturday night.
Week 5 predictions for each of the 55 FBS games:
| Matchup | Winner |
|---|---|
| Navy vs. Memphis | Memphis |
| Duke vs. Virginia Tech | Virginia Tech |
| Penn State vs. Maryland | Penn State |
| San Jose State vs. Air Force | Air Force |
| Arizona State vs. Cal | Cal |
| Texas Tech vs. Oklahoma | Oklahoma |
| Northwestern vs. Wisconsin | Wisconsin |
| Middle Tennessee vs. Iowa | Iowa |
| Rutgers vs. Michigan | Michigan |
| Texas A&M vs. Arkansas | Texas A&M |
| Holy Cross vs. Syracuse | Syracuse |
| Northern Illinois vs. Vanderbilt | Northern Illinois |
| Kansas vs. TCU | TCU |
| BYU vs. Toledo | Toledo |
| Buffalo vs. Miami (OH) | Miami (OH) |
| Central Michigan vs. Western Michigan | Western Michigan |
| Delaware vs. Pittsburgh | Pittsburgh |
| Clemson vs. North Carolina | Clemson |
| Ole Miss vs. Alabama | Alabama |
| Virginia vs. Notre Dame | Notre Dame |
| USC vs. Washington | Washington |
| Indiana vs. Michigan State | Michigan Staet |
| Florida Atlantic vs. Charlotte | Charlotte |
| Georgia Tech vs. Temple | Temple |
| Wake Forest vs. Boston College | Wake Forest |
| Iowa State vs. Baylor | Iowa State |
| Minnesota vs. Purdue | Purdue |
| Coastal Carolina vs. App State | App State |
| Akron vs. UMass | UMass |
| Towson vs. Florida | Florida |
| SMU vs. South Florida | SMU |
| Cincinnati vs. Marshall | Cincinnati |
| New Mexico vs. Liberty | Liberty |
| East Carolina vs. Old Dominion | Old Dominion |
| Arkansas State vs. Troy | Troy |
| Louisiana vs. Georgia Southern | Georgia Southern |
| Mississippi State vs. Auburn | Auburn |
| UConn vs. UCF | UCF |
| Kansas State vs. Oklahoma State | Oklahoma State |
| South Alabama vs. UL Monroe | UL Monroe |
| Nicholls vs. Texas State | Nicholls |
| UTEP vs. Southern Miss | Southern Miss |
| UAB vs. Western Kentucky | UAB |
| Louisiana Tech vs. Rice | Rice |
| Stanford vs. Oregon State | Stanford |
| Ohio State vs. Nebraska | Ohio State |
| NC State vs. Florida State | Florida State |
| Kentucky vs. South Carolina | Kentucky |
| Colorado State vs. Utah State | Utah State |
| UNLV vs. Wyoming | Wyoming |
| Fresno State vs. NM State | Fresno State |
| Houston vs. North Texas | North Texas |
| Washington State vs. Utah | Utah |
| UCLA vs. Arizona | Arizona |
| Hawai'i vs. Nevada | Hawai'i |
