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Delaware vs. Colorado Prediction, Betting Odds & How To Watch

Colton Pool by Colton Pool
September 5, 2025
Delaware head coach Ryan Carty

AP Photo/Nick Wass

This is a battle between a team that’s new to Conference USA and a quarterback who used to play in the league.

Former Liberty quarterback Kaidon Salter will look to lead the Colorado Buffaloes to their first win of the season after losing to Georgia Tech last week. Colorado is facing Delaware, which is in its first season in the FBS. The Blue Hens won their first game of the year over Delaware State, but they’ve got a tougher test this time around.


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Delaware vs. Colorado Betting Odds

Colorado is a -23.5 college football betting odds favorite against Delaware, with the Over/Under being 50.5.

The moneyline for Delaware is +1100, while it’s -2500 for Colorado.


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Delaware vs. Colorado On TV

The matchup between Delaware and Colorado will be televised on FOX.

The game will kick off at 3:30 p.m. ET on Saturday, Sept. 6. The contest is taking place at Folsom Field in Boulder, Colorado.

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Delaware vs. Colorado Prediction

I predict Colorado will win and cover the 23.5-point spread. I also project the game will go Over 50.5 total points.

We’ve seen in the past where first-year FBS teams take a year to acclimate to the new level. While I do think Delaware could one day be competitive in CUSA, I don’t expect the Blue Hens to have a winning record this year.

And Colorado should be highly motivated to take care of business and get a win here. If the Buffaloes lose, their season could spiral out of control.

And that’s why I think they’ll fix some mistakes and win this contest decisively. 

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