Leading Georgia Southern the past few years, Clay Helton has helped the Eagles become a true Sun Belt Championship contender in 2025.
Now his current team will face his former team.
Helton and Georgia Southern will take on USC, where Helton was the head coach from 2016-21. He went 46-24 while there.
Georgia Southern vs. USC Betting Odds
USC is a -28.5 college football betting odds favorite against Georgia Southern, with the Over/Under being 60.5.
The moneyline for Georgia Southern is +1600, while it’s -5000 for USC.
Georgia Southern vs. USC On TV
The matchup between Georgia Southern and USC will be televised on FS1.
The game will kick off at 7:30 p.m. ET on Saturday, Sept. 6. The contest is taking place at Los Angeles Memorial Coliseum in Los Angeles, California.
Georgia Southern vs. USC Prediction
I predict USC will win but Georgia Southern will cover the 28.5-point spread. I also project the game will go Over 60.5 total points.
There’s no doubt the season didn’t start how Georgia Southern wanted it to. The Eagles lost 42-14 at Fresno State while totaling just 242 yards of offense.
After an inconsistent game last week, I think quarterback JC French IV will bounce back in this matchup. I also expect Georgia Southern’s rushing attack to fix some mistakes from last week.
Now, I’m not saying the Eagles are going to beat USC. But I do think last week wasn’t reflective of what Georgia Southern can do. I believe the Eagles have enough offensive firepower to make this matchup interesting in the first half and will ultimately lose by less than four touchdowns.
