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SMU vs. Missouri State Prediction, Betting Odds & How To Watch

Colton Pool by Colton Pool
September 12, 2025
Missouri State head coach Ryan Beard

AP Photo/Charlie Riedel

This is a matchup between a team that used to be in the Group of Five and another that is in its first year in a G5 conference.

Missouri State earned its first victory as an FBS program last week in a 21-20 win against Marshall on the road. Even if the Bears are new to Conference USA, they might prove to be a tough matchup once they start league play.

But first, they’re hosting SMU, which is in its second year in the ACC after previously playing in the American. SMU made it to the College Football Playoff last year, so this is unlikely to be an easy contest for Missouri State.

SMU vs. Missouri State Betting Odds

Missouri State is a +27.5 college football betting odds underdog against SMU, with the Over/Under being 60.5.

The moneyline for SMU is -10000, while it’s +1700 for Missouri State.


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SMU vs. Missouri State On TV

The matchup between SMU and Missouri State will be televised on CBSSN.

The game will kick off at 3:30 p.m. ET on Saturday, Sept. 13. The contest is taking place at Robert W. Plaster Stadium in Springfield, Missouri.

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SMU vs. Missouri State Prediction

I predict SMU will win and cover the 27.5-point spread. I also project this game will go Under 60.5 total points.

Missouri State just had a gutsy performance in its win over Marshall. To win like that over a storied program in their first season in the FBS, I think the Bears will cause some problems for CUSA teams.

But I don’t expect this will be a problem for SMU. The Mustangs just barely lost to Baylor last week, and they should be motivated to bounce back if they want any chance of getting back to the College Football Playoff this season.

I’m expecting SMU’s offense will score early and often on the road. I’m also anticipating SMU’s defense will rebound after giving up 48 points to Baylor a week ago.

And ultimately I believe SMU will have an insurmountable lead by intermission.

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